Scientists have made significant strides in identifying new genes associated with a heightened risk of colon and rectal cancer.

This breakthrough may play a pivotal role in enhancing our understanding of the prevention and treatment of this widespread form of malignancy.

Researchers hailing from the Vanderbilt-Ingram Cancer Center in the United States have undertaken an extensive transcriptomic-wide association study (TWAS) along with an alternative approach known as splicing-TWAS to bolster their gene discovery efforts.

TWAS serves as a genetic methodology that allows for the comparison of genetic elements responsible for gene expression with those contributing to a particular trait, enabling the determination of potential associations between the two components.

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